Asia-Pacific Journal of Oncology Nursing

REVIEW ARTICLE
Year
: 2019  |  Volume : 6  |  Issue : 3  |  Page : 238--245

Radiation Fibrosis Syndrome: The Evergreen Menace of Radiation Therapy


Abhishek Purkayastha1, Neelam Sharma2, Arti Sarin3, Sharad Bhatnagar4, Nilotpal Chakravarty2, Hari Mukundan5, Virender Suhag1, Sankalp Singh4 
1 Department of Radiation Oncology, Command Hospital (Southern Command), Pune, Maharashtra, India
2 Department of Radiation Oncology, Army Hospital Research and Referral, New Delhi, India
3 Department of Radiation Oncology, INHS Asvini, Mumbai, Maharashtra, India
4 Department of Radiation Oncology, Command Hospital (Central Command), Lucknow, Uttar Pradesh, India
5 Department of Radiation Oncology, Command Hospital (Air Force), Bengaluru, Karnataka, India

Correspondence Address:
Abhishek Purkayastha
Department of Radiation Oncology, Command Hospital (Southern Command), Pune, Maharashtra
India

Fibrosis is a descriptive appellation referring to the obliteration of normal tissue components replaced by matrix and disorganized and varied collagen fibrils that result in the loss of organ function and frequent tissue contraction leading to death or significant deterioration in the quality of life. Radiation fibrosis syndrome (RFS) is a progressive fibrotic tissue sclerosis with various clinical symptoms in the irradiation field. It is usually a late complication of radiation therapy and may occur weeks or even years after treatment. It may affect the musculoskeletal, soft tissue, neural tissue, and cardiopulmonary systems. RFS is a serious and lifelong disorder that, nevertheless, may often be prevented when identified and rehabilitated early. Genetic factors likely play a significant role in the development of chronic fibrotic response to radiation injury that persists even after the initial insult is no longer present. Management of this syndrome is a complex process comprising medication, education, rehabilitation, and physical and occupational therapy. A bibliographical search was carried out in PubMed using the following keywords: “radiation fibrosis,” “radiation fibrosis syndrome,” and “radiation-induced fibrosis.” We also reviewed the most relevant and recent series on the current management of RFS, and the reviewed data are discussed in this article. This review discusses the pathophysiology, evaluation, and treatment of neuromuscular, musculoskeletal, and functional disorders as late effects of radiation treatment.


How to cite this article:
Purkayastha A, Sharma N, Sarin A, Bhatnagar S, Chakravarty N, Mukundan H, Suhag V, Singh S. Radiation Fibrosis Syndrome: The Evergreen Menace of Radiation Therapy.Asia Pac J Oncol Nurs 2019;6:238-245


How to cite this URL:
Purkayastha A, Sharma N, Sarin A, Bhatnagar S, Chakravarty N, Mukundan H, Suhag V, Singh S. Radiation Fibrosis Syndrome: The Evergreen Menace of Radiation Therapy. Asia Pac J Oncol Nurs [serial online] 2019 [cited 2020 Nov 28 ];6:238-245
Available from: https://www.apjon.org/article.asp?issn=2347-5625;year=2019;volume=6;issue=3;spage=238;epage=245;aulast=Purkayastha;type=0