Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 224
  • Home
  • Print this page
  • Email this page

 Table of Contents  
Year : 2019  |  Volume : 6  |  Issue : 3  |  Page : 227-233

Evaluation of the True Endpoint of Clinical Trials for Cancer Cachexia

Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan

Date of Submission24-Oct-2018
Date of Acceptance05-Nov-2018
Date of Web Publication30-Apr-2019

Correspondence Address:
Tateaki Naito
Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/apjon.apjon_68_18

Rights and Permissions

Cachexia is an old disease but a new research area that has recently been vigorously investigated. The diagnostic and staging criteria for cancer-associated cachexia have been established through an international consensus report (CR) published in 2011, which may greatly influence the designs and interventions of future clinical trials. However, no standard treatment has been established so far. This may be partially due to the lack of a widely accepted common endpoint for clinical trials. This review aimed to summarize designs and endpoints of 65 randomized controlled trials for cancer cachexia in the past 16 years and seek clinically relevant patient-centered outcomes for future clinical trials. Compared with trials before the CR, trials after the report revealed that the study populations tended to be at the earlier stage of cachexia and included patients with precachexia or those at risk for cachexia. Nonpharmacological interventions have been widely tested, and functional endpoints have increasingly been selected in combination with standard endpoints of body mass or lean body mass. Disability-free survival has recently been used as a functional endpoint in clinical trials in several research fields. It might be also a suitable patient-centered outcome responsive to multiple physical changes in cancer cachexia, and patients might find it more acceptable than other classical endpoints. More efforts would be needed to identify an optimal measurable endpoint and establish a better combination of pharmacological and nonpharmacological interventions to improve the functional prognosis for patients with cancer cachexia.

Keywords: Cancer cachexia, disability, endpoint, functional prognosis, patient-centered outcome

How to cite this article:
Naito T. Evaluation of the True Endpoint of Clinical Trials for Cancer Cachexia. Asia Pac J Oncol Nurs 2019;6:227-33

How to cite this URL:
Naito T. Evaluation of the True Endpoint of Clinical Trials for Cancer Cachexia. Asia Pac J Oncol Nurs [serial online] 2019 [cited 2021 Oct 18];6:227-33. Available from: https://www.apjon.org/text.asp?2019/6/3/227/252395

  Introduction Top

Wasting conditions associated with various inflammatory diseases have been known since ancient time. In Greece, Hippocrates precisely described the core pathogenesis of cachexia, wherein “the flesh is consumed and becomes water” and considered cachexia as a sign of death.[1] In ancient China, a similar wasting condition, limpness, was described in an old textbook and reported to be induced by chronic inflammatory diseases in various organs.[2] According to the account, the patient's muscles in the trunk and lower limbs had atrophy, which resulted in difficulties in standing up or walking. The unfavorable impact of cachexia on functional prognosis has been more emphasized than that on survival prognosis. In the Middle East, Avicenna, a medieval Arab scholar, also stated the importance of avoiding a cachectic condition for the maintenance of healthy and active life, especially in the elderly population.[3] Despite this long history of cachexia in humans, there is limited understanding of such condition. This may be partial because cachexia is a functional disorder and its primary cause is macroscopically invisible.

Based on recent advances in medicine, the pathophysiology of cachexia is known to involve multiple organs including skeletal muscles, adipose tissues, and the digestive, immune, or central nervous system.[4] However, this may only be the initial step in identifying the core mechanism shared by many pro-cachectic diseases, including pulmonary, cardiac, malignant, rheumatic, and renal disease.[5] With regard to cancer-associated cachexia, it was a pivotal step to achieve consensus about specific diagnostic and staging criteria.[6] Through that consensus report (CR), cancer cachexia can be easily diagnosed using a few anthropometric measurements and quick interview. Furthermore, the CR has taught that cachexia could develop not only in the terminal phase but also in the very early phase of the cancer trajectory. Cachexia can insidiously start and progress immediately after or even before the diagnosis of cancer. In addition, the CR proposed the development of a multimodal intervention by combining nutritional, physical, and psychosocial interventions. These framework and future direction of care possibly can greatly impact the designs and interventions of future clinical trials. However, the ultimate goal of cancer cachexia care and clinical trials remains to be elucidated. There are discrepancies in recognition of clinically relevant outcomes among researchers, pharmaceutical companies, and regulatory authorities. One of the newly developed ghrelin receptor agonists, anamorelin, has constantly been associated with a significant increase in lean body mass, weight, and appetite among patients with advanced nonsmall cell lung cancer (NSCLC) in two large-scale randomized phase III studies.[7] However, the drug was refused for marketing authorization by the European Medicines Agency (EMA) because of the potential risks outweigh the benefits.[8] The EMA concluded that the efficacy of anamorelin was not established because there was only a marginal effect on lean body mass and no reliable and clinically relevant effect on patient functioning or quality of life (QOL).

Therefore, there is an urgent need to reconsider the clinically relevant endpoints of clinical trials for cancer cachexia that simultaneously meet the demands from patients, researchers, and regulatory authorities. This review aimed to explore changes in designing clinical trials after the publication of the CR and discuss optimal patient-centered outcomes in future clinical trials for cancer cachexia.

  Methods Top

Randomized controlled trials (RCTs) were identified by searching the PubMed using the following keywords: (cachexia [tiab] OR cachectic [tiab] OR malnutrition [Mesh] OR malnutrition [tiab] OR “muscle wasting” [tiab] OR “muscular wasting” [tiab] OR “muscle weakness”[Mesh] OR “muscle weakness” [tiab] OR “muscular weakness&” [tiab] OR sarcopenia [tiab] OR “wasting syndrome” [MeSH: noexp] OR “wasting syndrome” [tiab] OR “weight loss” [tiab]) AND (neoplasms [MeSH] OR cancer [tiab] OR tumor [tiab] OR tumour [tiab] OR neoplas [tiab] OR malignan [tiab] OR carcinoma [tiab] OR adenocarcinoma [tiab] OR choricarcinoma [tiab] OR leukemia [tiab] OR leukaemia [tiab] OR metastat [tiab] OR sarcoma [tiab] OR teratoma [tiab]). The prespecified inclusion criteria were articles in the English language, articles published between January 2003 and September 2018, studies involving adults, and RCTs. Studies on hematologic malignancies, surgically operable cancers, cancer survivors, or noncancer populations were excluded. RCTs published within 8 years before the CR (2003–2010) were classified as the pre-CR group, whereas those published within 8 years after the CR (2011–2018) were classified as the post-CR group. Entry criteria, the cachectic status of participants, concurrent treatments, and type of intervention were compared between the groups. Data on primary, secondary, and exploratory endpoints of each study were collected and compared between the groups.

Time-to-event curves were generated using the Kaplan–Meier method. Time-to-event was calculated as the time from the entry of the study to the date of the event, or last visit of the patients for whom the date of the event could not be confirmed. The database of a previous prospective observational study that recruited 60 elderly patients with newly diagnosed locally advanced or metastatic NSCLC who were to start chemotherapy and/or radiotherapy (trial registration no. UMIN000009768,[9]) was used, in which the physical parameters of the patients such as weight, shuttle walking distance, and handgrip strength were regularly measured without any nutritional or exercise interventions. The event of cancer cachexia was defined as having ≥5% loss in the body weight within 6 months before participating in the study. The event of walking disturbance was defined as having a ≥10% decline in the incremental shuttle walking distance from the baseline value. The event of muscle weakness was defined as having ≥10% decline in handgrip strength from the baseline value. A disabling event was defined as having ≥10 points decline in the Barthel index from the baseline value.

  Results Top

Overview of randomized controlled trials for cancer cachexia

A total of 65 RCT articles published between January 2003 and August 2018 were identified in PubMed; the reference list is shown in [Supplementary Table 1] [Additional file 1]. Twenty-one trials comprised the pre-CR group, and 44 trials comprised the post-CR group [Table 1]. According to the definitions in the CR,[6] 46 (71%) studies were designed to include patients with cancer cachexia. Among these studies, 12 (18%) potentially included patients with precachexia. Patients with refractory cachexia were excluded in most of the studies, while performance status or expected life expectancy was used as exclusion criteria. Approximately 19 (29%) studies recruited patients at risk for cachexia regardless of the presence of anorexia or weight loss. These were patients who underwent radiotherapy with or without chemotherapy for treatment of locally advanced head and neck, thoracic, or gynecological cancer, or patients with metastatic cancers who received palliative chemotherapy or care. In the post-CR group, the number of studies for patients with cachexia decreased, while that for patients with precachexia or patients at risk for cachexia increased.
Table 1: Characteristics of 65 randomized controlled trials for patients with cachexia before and after the international consensus report on cancer cachexia

Click here to view

With regard to cancer types and concurrent treatment modalities, most studies included a mixed population. After the CR, the proportion of studies for patients with specific cancer types receiving active cancer treatment was increasing. The major concurrent cancer treatments included palliative chemotherapy (20%) and radiotherapy with or without chemotherapy (15%). A total of 37 (57%) pharmacological interventions were tested, including single or combined use of omega-3 fatty acids, megestrol acetate, thalidomide, L-carnitine, anti-cytokines, nonsteroidal anti-inflammatory drugs, cannabinoids, ghrelin or its analogs, selective androgen receptor modulators, and others. Nonpharmacological interventions were tested in 28 (43%) studies, mostly in the post-CR group. Among these interventions, nutritional counseling with or without the use of oral nutritional supplements was the most common, and the proportion of studies involving such had doubled after the CR.

Common endpoints in randomized controlled trials for cancer cachexia

Endpoints tested in the listed studies are summarized in [Table 2]. They were classified into eight components as follows: body mass, nutritional status, physical function, symptoms, QOL, prognosis, use of medical resources, tolerance to cancer treatment, and biomarkers. The three most commonly assessed endpoints were body weight or body mass index (49 studies, 75%), global QOL (43 studies, 66%), and lean body mass (31 studies, 48%). Lean body or skeletal muscle mass was measured using dual-energy X-ray absorptiometry, bioelectrical impedance analysis, or computed tomography. The major questionnaires used for the assessment of global QOL were the European Organisation for Research and Treatment of Cancer QOL Questionnaire-Core 30 (40 studies) and the Functional Assessment of Anorexia/Cachexia Therapy (14 studies). Nutritional status was assessed in 23 (35%) studies, and the major endpoints included the amount of food intake and nutritional assessment tools such as the Patient-Generated Subjective Global Assessment. Physical function was assessed in 21 (32%) studies, and the major endpoints included performance status and handgrip strength. Recently, assessments for walking capacity have been increasingly adopted as endpoints, including field walking tests, performance tests for the lower limbs, and physical activity measured by pedometers/accelerometers.
Table 2: Classification of endpoints in randomized controlled trials for patients with cachexia

Click here to view

Overall survival was selected as a prognostic indicator in 21 (32%) studies but rarely had positive results even in studies that showed improvements in weight or lean body mass.[10],[11],[12] Studies focusing on the use of medical resources have recently emerged (3 studies, 5%). Length of hospital stay and medical costs were assessed.[10],[13],[14] Moreover, the protective effects of interventions on the toxicity of radiotherapy or chemotherapy were assessed in several studies. Inflammatory and nutritional biomarkers were assessed in 25 (38%), and 21 (32%) studies and the major items were C-reactive protein, albumin, prealbumin, interleukin-6, and tumor necrosis factor-alpha.

  Discussion Top

Functional prognosis and disability-free survival

The ultimate goal of care for cancer cachexia has not been established. The selection of endpoints, measuring scales, or statistical analysis varies with the hypothesis or preference of researchers, pharmaceutical companies, and regulatory authorities.[15] These variations in the selection of endpoints might decrease the comparability of the results of clinical trials and impede the development of effective treatment. Although concomitant improvement in skeletal muscle mass, physical function, QOL, and overall survival may be the ideal goal, these parameters do not always correlate with each other. For example, gain in lean body mass was not always associated with improvement in physical function [7], 11, [16],[17],[18] or QOL [11],[18],[19] among the listed studies.

This review proposes the model of the sequential relationship between physical events in patients with advanced lung cancer [Figure 1]. This model was developed by the results of a previous prospective observational study that recruited elderly patients with advanced NSCLC.[9] In this aspect, sequential physical losses may begin early during cancer trajectory and continue until death. The earliest event among the patients was weight loss. More than half of the patients demonstrated ≥ 5% weight loss at the time of the study, suggesting that cachexia may start before the diagnosis of advanced cancer. In the following months, walking capacity and muscle strength declined. These physical losses finally resulted in disabling events, which were defined as a 10-point decrease in the Barthel index from baseline and occurred at a median of 13 months from baseline.
Figure 1: Sequential functional events in cancer trajectory in elderly patients with advanced lung cancer. Blue curve: event of cancer cachexia. Aqua curve: event of walking disturbance. Green curve: event of muscle weakness. Orange curve: disabling event. Red curve: overall survival

Click here to view

The disability-free survival (DFS) curve occurred slightly below the overall survival curve with a slightly high-pitched slope. This study proposes DFS as a new measurable indicator of functional prognosis in cancer cachexia because disabling events reflect the multiple physical losses due to cancer cachexia and are independent of a death event.[20] Due to the advances in medical fields and changes in lifestyle, humans are now able to lead a physically vigorous life until shortly before the biologically fixed lifespan end. People increasingly wish for an active long life despite the presence or absence of incurable diseases.[21] DFS originally corresponds to the disability-free life expectancy in epidemiological studies.[22] Recently, DFS has been introduced as a relevant patient-centered outcome of clinical trials in the fields of perioperative,[23],[24] geriatric,[25] and pediatric medicine.[26] However, it is rarely selected as an endpoint of oncological clinical trials. A previous study reported that the presence of cancer cachexia at baseline was strongly associated with short DFS and long postdisability survival in elderly patients with advanced cancer.[27] In addition, this endpoint was associated with increased use of medical resources, including frequent unplanned visits, longer hospital stay, and higher cumulative medical costs. All of these measurements were considered important by their caregivers and healthcare providers.

Future direction of clinical trials for cancer cachexia

A new nonpharmacological multimodal intervention for cancer cachexia called the Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) program, is being developed. It combined nutritional counseling, low-intensity home-based resistance training, and promotive counseling of physical activity and was designed to prevent disability in elderly patients at risk for cachexia who are newly diagnosed with advanced NSCLC or pancreatic cancer and are to start systemic chemotherapy. Results of the Phase I feasibility study of this new intervention (NEXTAC-ONE) have been reported elsewhere.[28] A total of 30 participants showed excellent attendance (96.7%) and compliance for each intervention (≥90%) in the program, with only one dropout. The majority of patients was also adhered to the health education that was conducted and changed their health-related behavior such as increasing indoor or outdoor activity.[29] No severe adverse event occurred. Consequently, a prospective, multicenter, randomized Phase II clinical trial (NEXTAC-TWO, trial registration no. UMIN000028801) is being conducted to improve DFS in elderly patients with advanced cancer. A total of 130 patients are planned to be randomized to usual care or usual care plus NEXTAC in a 1:1 ratio. It was hypothesized that the NEXTAC prolongs 4 months of DFS from the usual care with 80% power. If this program could be proved to be both feasible and effective, it will be combined with newly emerging pharmacological interventions for cachexia to further improve functional prognosis and socioeconomic outcomes in elderly patients with advanced cancer.


This review has several limitations. First, the literature search was carried out using only PubMed. A single reviewer (TN) carried out the selection of articles for inclusion. These drawbacks may result in a potential selection bias in the establishment of a reference list for RCTs. Second, not only the primary endpoint but also secondary and exploratory endpoints were included, without weighing the evidence that was shown in each study. Finally, the database used for the time-to-event curves included small samples from a single institution in Japan. Based on these limitations, we should pay careful attention while interpreting the results.

  Conclusion Top

Clinical trials evaluating treatments for cancer cachexia are increasing. After the international consensus on the diagnostic and staging criteria for cancer cachexia, most clinical trials selected study populations in the earlier stage of the disease and the intervention tended to start earlier, concurrent with active cancer treatment. The true endpoint of these studies may be the expansion of active life with better QOL. Although the classical endpoint of increasing body mass would be an important outcome, it may not always contribute as a true endpoint. Thus, an optimal measurable endpoint should be identified, and a better combination of pharmacological and nonpharmacological interventions be established to improve functional prognosis in patients with this long-standing disease.


The author would like to thank the patients and their families for taking part in this study, as well as the investigators and staffs in the division of Thoracic Oncology in the Shizuoka Cancer Center, Japan. The author would like to acknowledge Toshiaki Takahashi, MD, Koichi Takayama, MD, and Kazuo Tamura, MD for their generous instruction and support in conducting research for cancer cachexia.

Financial support and sponsorship

This study (UMIN000023207) was supported by the Japan Agency for Medical Research and Development (AMED) under grant number JP18ck0106212.

Conflicts of interest

There are no conflicts of interest.

  References Top

Katz AM, Katz PB. Diseases of the heart in the works of Hippocrates. Br Heart J 1962;24:257-64.  Back to cited text no. 1
Unschuld PU. Huang Di Neijing Su Wen. Berkeley, Los Angeles: University of California Press; 2011.  Back to cited text no. 2
Nimrouzi M, Zare M. Principles of nutrition in Islamic and traditional Persian medicine. J Evid Based Complementary Altern Med 2014;19:267-70.  Back to cited text no. 3
Argilés JM, Busquets S, Stemmler B, López-Soriano FJ. Cachexia and sarcopenia: Mechanisms and potential targets for intervention. Curr Opin Pharmacol 2015;22:100-6.  Back to cited text no. 4
von Haehling S, Anker SD. Prevalence, incidence and clinical impact of cachexia: Facts and numbers-update 2014. J Cachexia Sarcopenia Muscle 2014;5:261-3.  Back to cited text no. 5
Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: An international consensus. Lancet Oncol 2011;12:489-95.  Back to cited text no. 6
Temel JS, Abernethy AP, Currow DC, Friend J, Duus EM, Yan Y, et al. Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): Results from two randomised, double-blind, phase 3 trials. Lancet Oncol 2016;17:519-31.  Back to cited text no. 7
European Medicines Agency. Adlumiz: EPAR – Refusal Public Assessment Report. Available from: https://www.ema.europa.eu/medicines/human/EPAR/adlumiz. [Last accessed on 2018 Oct 14].  Back to cited text no. 8
Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, et al. Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non-small-cell lung cancer. BMC Cancer 2017;17:571.  Back to cited text no. 9
Kraft M, Kraft K, Gartner S, Mayerle J, Simon P, Weber E, et al. L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN)-a randomized multicentre trial. Nutr J 2012;11:52.  Back to cited text no. 10
Gordon JN, Trebble TM, Ellis RD, Duncan HD, Johns T, Goggin PM. Thalidomide in the treatment of cancer cachexia: A randomised placebo controlled trial. Gut 2005;54:540-5.  Back to cited text no. 11
Jatoi A, Rowland K, Loprinzi CL, Sloan JA, Dakhil SR, MacDonald N, et al. An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: A North Central Cancer Treatment Group and National Cancer Institute of Canada collaborative effort. J Clin Oncol 2004;22:2469-76.  Back to cited text no. 12
De Waele E, Mattens S, Honore PM, Spapen H, De Greve J, Pen JJ. Nutrition therapy in cachectic cancer patients. The Tight Caloric Control (TiCaCo) pilot trial. Appetite 2015;91:298-301.  Back to cited text no. 13
Cong MH, Li SL, Cheng GW, Liu JY, Song CX, Deng YB, et al. An interdisciplinary nutrition support team improves clinical and hospitalized outcomes of esophageal cancer patients with concurrent chemoradiotherapy. Chin Med J (Engl). 2015;128:3003-7.  Back to cited text no. 14
Fearon K, Argiles JM, Baracos VE, Bernabei R, Coats A, Crawford J, et al. Request for regulatory guidance for cancer cachexia intervention trials. J Cachexia Sarcopenia Muscle 2015;6:272-4.  Back to cited text no. 15
Takayama K, Katakami N, Yokoyama T, Atagi S, Yoshimori K, Kagamu H, et al. Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: Results of a randomized phase 2 trial. Support Care Cancer 2016;24:3495-505.  Back to cited text no. 16
Maccio A, Madeddu C, Gramignano G, Mulas C, Floris C, Sanna E, et al. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: Evaluating the impact on metabolic and inflammatory profiles and quality of life. Gynecol Oncol 2012;124:417-25.  Back to cited text no. 17
Dobs AS, Boccia RV, Croot CC, Gabrail NY, Dalton JT, Hancock ML, et al. Effects of enobosarm on muscle wasting and physical function in patients with cancer: A double-blind, randomised controlled phase 2 trial. Lancet Oncol 2013;14:335-45.  Back to cited text no. 18
Mantovani G, Maccio A, Madeddu C, Serpe R, Massa E, Dessi M, et al. Randomized phase III clinical trial of five different arms of treatment in 332 patients with cancer cachexia. Oncologist 2010;15:200-11.  Back to cited text no. 19
Gill TM, Gahbauer EA, Han L, Allore HG. Trajectories of disability in the last year of life. N Engl J Med 2010;362:1173-80.  Back to cited text no. 20
Fries JF. Aging, natural death, and the compression of morbidity. N Engl J Med 1980;303:130-5.  Back to cited text no. 21
Katz S, Branch LG, Branson MH, Papsidero JA, Beck JC, Greer DS. Active life expectancy. N Engl J Med 1983;309:1218-24.  Back to cited text no. 22
Shulman MA, Myles PS, Chan MT, McIlroy DR, Wallace S, Ponsford J. Measurement of disability-free survival after surgery. Anesthesiology 2015;122:524-36.  Back to cited text no. 23
Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D, et al. Restrictive versus liberal fluid therapy for major abdominal surgery. N Engl J Med 2018;378:2263-74.  Back to cited text no. 24
McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, et al. Effect of aspirin on disability-free survival in the healthy elderly. N Engl J Med 2018;379:1499-508.  Back to cited text no. 25
Osborn DA, Schindler T, Jones LJ, Sinn JK, Bolisetty S. Higher versus lower amino acid intake in parenteral nutrition for newborn infants. Cochrane Database Syst Rev 2018;3:CD005949.  Back to cited text no. 26
Naito T, Okayama T, Aoyama T, Ohashi T, Masuda Y, Kimura M, et al. Unfavorable impact of cancer cachexia on activity of daily living and need for inpatient care in elderly patients with advanced non-small-cell lung cancer in Japan: A prospective longitudinal observational study. BMC Cancer 2017;17:800.  Back to cited text no. 27
Naito T, Mitsunaga S, Miura S, Tatematsu N, Inano T, Mouri T, et al. Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non-small-cell lung cancer. J Cachexia Sarcopenia Muscle 2018;18. doi: 10.1002/jcsm.12351. [Epub ahead of print] PMID: 30334618.  Back to cited text no. 28
Mouri T, Naito T, Morikawa A, Tatematsu N, Miura S, Okayama T, et al. Promotion of behavioral change and the impact on quality of life in elderly patients with advanced cancer: A physical activity intervention of the multimodal nutrition and exercise treatment for advanced cancer program. Asia Pac J Oncol Nurs 2018;5:383-90.  Back to cited text no. 29
[PUBMED]  [Full text]  

  Authors Top

Tateaki Naito


  [Figure 1]

  [Table 1], [Table 2]

This article has been cited by
1 Impact of Physical Inactivity on the Risk of Disability and Hospitalization in Older Patients with Advanced Lung Cancer
Yusuke Yonenaga,Tateaki Naito,Taro Okayama,Midori Kitagawa,Noriko Mitsuhashi,Takeshi Ishii,Hiroshi Fuseya,Toshimi Inano,Ayumu Morikawa,Miwa Sugiyama,Keita Mori,Akifumi Notsu,Takanori Kawabata,Akira Ono,Hirotsugu Kenmotsu,Haruyasu Murakami,Akira Tanuma,Toshiaki Takahashi
Journal of Multidisciplinary Healthcare. 2021; Volume 14: 1521
[Pubmed] | [DOI]
2 A multimodal approach to cancer-related cachexia: from theory to practice
Alice Avancini,Ilaria Trestini,Daniela Tregnago,Massimo Lanza,Jessica Menis,Lorenzo Belluomini,Michele Milella,Sara Pilotto
Expert Review of Anticancer Therapy. 2021; : 1
[Pubmed] | [DOI]
3 Impact of Body Weight Loss on Survival in Patients with Advanced Gastric Cancer Receiving Second-Line Treatment
Takuro Mizukami,Koki Hamaji,Risa Onuki,Ayako Yokomizo,Yoshie Nagashima,Hiroyuki Takeda,Kumiko Umemoto,Ayako Doi,Hiroyuki Arai,Mami Hirakawa,Yoshiki Horie,Naoki Izawa,Takashi Ogura,Takashi Tsuda,Yu Sunakawa,Michi Shibata,Tsuneaki Tanaka,Shinya Mikami,Takako Eguchi Nakajima
Nutrition and Cancer. 2021; : 1
[Pubmed] | [DOI]
4 Exercise Training as Therapeutic Approach in Cancer Cachexia: A Review of Potential Anti-inflammatory Effect on Muscle Wasting
Luana G. Leal,Magno A. Lopes,Sidney B. Peres,Miguel L. Batista
Frontiers in Physiology. 2021; 11
[Pubmed] | [DOI]
5 Challenges in enhancing physical performance in thoracic cancer cachexia
Tateaki Naito
Thoracic Cancer. 2021;
[Pubmed] | [DOI]
6 Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition
Barbara Troesch,Manfred Eggersdorfer,Alessandro Laviano,Yves Rolland,A. David Smith,Ines Warnke,Arved Weimann,Philip C. Calder
Nutrients. 2020; 12(9): 2555
[Pubmed] | [DOI]
7 Theoretical and Practical Implications of Treating Cachexia in Advanced Lung Cancer Patients
Philip Bonomi,Mary Jo Fidler,Palmi Shah,Jeffrey Borgia
Cancers. 2019; 11(11): 1619
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Article Figures
Article Tables

 Article Access Statistics
    PDF Downloaded585    
    Comments [Add]    
    Cited by others 7    

Recommend this journal