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 Table of Contents  
ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 218-224

Giving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients


1 Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands
2 Department of Medical Oncology, Màxima Medical Centre, Eindhoven, Netherlands
3 Departments of Medical Oncology, Leiden University Medical Centre, Leiden, The, Netherlands
4 Department of Psychological Science University of California, Merced, CA, USA
5 Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand
6 Medical Psychology, Leiden University Medical Centre, Leiden, The, Netherlands

Date of Submission20-Nov-2019
Date of Acceptance03-Feb-2020
Date of Web Publication30-Mar-2020

Correspondence Address:
PhD Corina van den Hurk
Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht
Netherlands
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/apjon.apjon_8_20

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  Abstract 


Objective: Individuals with cancer experience the impact of chemotherapy on hair loss in different ways. The aim of this pilot study was to explore patients' experiences of alopecia through patients' drawings. Methods: Fifteen female patients diagnosed with cancer and treated with chemotherapy were recruited at the oncological day-care unit of a teaching hospital in the Netherlands. Participants completed a semi-structured interview about alopecia. They drew their head and hair before and during chemotherapy and completed the Brief Illness Perception Questionnaire (B-IPQ).Results: The drawings revealed predominantly physical effects, rather than emotions. Emotions were evident in the text that patients wrote under the drawings and in the B-IPQ open question about the perceived consequences of alopecia. The overall impact of alopecia that emerged from the drawings and the B-IPQ corresponded to the information retrieved from the interviews, namely disappointment, insecurity, sadness, and confrontation.Conclusions: Drawings expose cognitive and emotional responses to alopecia that may be relatively unexplored when using traditional assessment methods such as questionnaires or interviews. In future research, the drawing instructions need to be more specifically focused on feelings in order to better capture emotional reactions to hair loss.

Keywords: Alopecia, cancer, chemotherapy, drawings, emotions, illness perceptions


How to cite this article:
Alphen Kv, Versluis A, Dercksen W, de Haas H, Lugtenberg R, Tiemensma J, Kroep J, Broadbent E, Kaptein AA, den Hurk Cv. Giving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients. Asia Pac J Oncol Nurs 2020;7:218-24

How to cite this URL:
Alphen Kv, Versluis A, Dercksen W, de Haas H, Lugtenberg R, Tiemensma J, Kroep J, Broadbent E, Kaptein AA, den Hurk Cv. Giving A Face to Chemotherapy-Induced Alopecia: A Feasibility Study on Drawings by Patients. Asia Pac J Oncol Nurs [serial online] 2020 [cited 2020 May 25];7:218-24. Available from: http://www.apjon.org/text.asp?2020/7/2/218/281605


  Introduction Top


One frequently occurring side effect of chemotherapy is alopecia. In the Netherlands, over 15,000 cancer patients face alopecia every year. Patients often lose hair on the head, eyelashes, eyebrows, and other parts of their body.[1] Once chemotherapy stops, hair will start to regrow in most patients.[2] Nevertheless, many patients are distressed by temporary alopecia.

Hair plays a particularly important role when it comes to our individuality, attractiveness, and appearance.[3] For many women, hair is seen as part of personality, sexuality, and femininity.[4] In addition, eyebrows and eyelashes play a major role in facial expressions.[1],[5] Emotional consequences of hair loss described in the literature include low self-esteem, anxiety, depression, negative body image, and reduced well-being.[6],[7] A bald head is characteristic of a person with cancer and signifies illness. Many women choose a wig to camouflage these aspects and to feel better.[8] In interviews, patients mention the importance of appearance in social situations and the experience of social distress due to alopecia.[9]

Alopecia is one of the side effects of chemotherapeutic treatment that has the largest emotional impact.[3] Patients are often ashamed when their hair starts to fall out. Cancer becomes visible, and this violates privacy.[10] Sometimes, hair loss is more traumatic for female breast cancer patients than the loss of a breast because it can be camouflaged less easily.[11] Hair loss can also contribute to reduced quality of life because patients are continuously reminded of their alopecia – and therefore cancer – in daily life.[12]

The impact of alopecia depends on the patient's expectations of alopecia, the amount of information given in advance, and a person's coping skills to deal with the situation.[11] Alopecia does not have the same impact on all patients. It can be regarded as very severe by some patients, whereas others see it as only a side effect.[13] In general, the impact of alopecia is underestimated by oncological health-care professionals.[14]

To date, the impact of alopecia has been assessed by interviews and questionnaires.[10],[12] Asking patients to draw their hair loss may reveal the impact of alopecia in a different way.[15] New insights might be created because patients are given the opportunity to choose how to draw their condition, instead of answering in limited categories in a questionnaire. A patient does not have to use words, like in an interview, which might make it easier for some people to express their feelings.[16] In this feasibility study, patients with cancer were asked to draw their head before and during chemotherapy. The drawings combined with responses to a questionnaire assessing illness perceptions, could provide a more complete overview of the impact of alopecia. Recent research has shown that drawings identify patients' illness representations. The drawings can be included as an additional outcome measure, for example, to predict time to return to work or the course of side effects. A systematic review study on drawing research by Broadbent et al. lists 101 studies about patients' drawings of their illness.[15]


  Methods Top


Patients

Participants (n = 15) were recruited from the oncological day-care unit of Máxima Medical Centre, a regional teaching hospital in the Netherlands, between October and November 2017. Patients were included if they had the prospect of severe alopecia, if they had had at least two chemotherapy treatments with or without scalp cooling, and if the last treatment was not longer than 1 month ago. If patients had no hair loss because of scalp cooling, they could still participate in this study. Patients needed to be proficient in Dutch and needed to be 18 years of age or older. Alopecia was defined as severe when patients were eligible for scalp cooling or were given a prescription for compensation for a wig by their health-care insurance. Patients were excluded from the study if they were bald before the start of the chemotherapy or when they had a mental condition which prohibited completing questionnaires, interviews, and drawings. At the days the researcher (KvA) was present at the day-care unit, the oncology nurses approached each eligible patient. The nurse informed the patients about the study and if they were willing to participate, written informed consent was obtained. Then, the researcher guided the patient through the assessments. The study was approved by the institutional medical ethics committee (ethics committee number N17.148).

Measures

This study was a cross-sectional pilot study that took place during chemotherapy in the hospital. Which chemotherapy session it was, differed per patient. Each patient followed the same sequence of assessments in a mixed-methods design that will be explained in detail below. In summary, they started with a qualitative oral interview, then they completed a drawing exercise which was quantitatively scored by the researchers. The patients also completed a qualitative description of the drawing, followed by a quantitative paper questionnaire including the Brief Illness Perception Questionnaire (B-IPQ) and sociodemographic and clinical characteristics.

Interview

The researcher (KvA) first interviewed the patient, addressing the following questions: (1) What did you (a) expect and (b) experience with regard to the impact of alopecia on your daily life? (2) Which aspect plays the most essential role when thinking about the impact of your alopecia: emotional, social, physical, body image, mood? The researcher especially focused on the emotional aspects mentioned to compare if these were also shown in the drawings. The interviews were audiotaped and transcribed verbatim and analyzed by one researcher (KvA). The transcripts were evaluated using content analysis. The researcher first assigned preliminary codes to the data, describing the content. Thereafter, patterns and themes were searched in the codes across the 15 interviews. These themes were finally defined and named.

Drawings

After the interview, the patient was asked to create at least two drawings (I and II) on an A4-piece of paper with three 10 cm × 10 cm boxes. The instructions (in Dutch) based on previous drawing research[17] were as follows:

Draw what your head and hair looked like before the start of chemotherapy (drawing I), during chemotherapy without head covering (drawing II) and (if applicable) another drawing with head covering (drawing III). We are not interested in your drawing ability, a simple sketch is fine. We are interested in your ideas about any changes in your appearance, only of your head and hair. You can choose to use colors in your drawings. Can you briefly describe what you have drawn on the dashed line beneath the drawings?

The drawings were scored on main characteristics by four independent observers: two applied psychology students (KvA, AV), a medical psychologist (AAK), and an epidemiologist (CvdH). The scoring forms with only Likert scales included facial expression (eyes, mouth, and total). The expressions were scored as “negative,” “neutral,” or “positive” and resulted in a final score after reaching consensus. The significance of the written text beneath the drawings was important for this pilot study to check on correspondence with the drawings and on additional information besides the drawings. The texts were for drawings I, II, and III separately categorized into domains by one researcher (KvA).

Brief Illness Perception Questionnaire

Finally, the patients filled out a newly developed score on the severity of hair loss, i.e. a pictorial combined with a Visual Analog Scale (0 = no hair loss and 100 = total hair loss) as well as the validated Dutch version of the B-IPQ.[18] Because this study was not targeting the perception of cancer itself but the perception of alopecia, the B-IPQ was adapted: the word “illness” was replaced by “alopecia.” The item about treatment control was omitted because patients mentioned that they did not understand the question and for most patients, their answers were not in line with their answers on other B-IPQ questions. This resulted in seven questions on a scale from 0 to 10, and an open question.[19] The open question was defined as: What are the three most important consequences of alopecia? The seven dimensions of the B-IPQ were consequences (how much alopecia influenced the patients' life), timeline (the perceived duration of the alopecia), personal control (how much patients felt in control of their alopecia), identity (physical complaints caused by alopecia), concern (to what extent, patients were concerned about alopecia), understanding (to what extent, patients understood their alopecia), and emotional response (how much alopecia had affected the patients emotionally).

The mean scores of the B-IPQ items/dimensions were calculated, and the answers to the open question about the most important consequences of alopecia were categorized by one researcher (KvA). The results were compared with the most applicable reference group, namely Dutch patients with breast cancer.[20] In that study, illness perceptions were assessed 2 months after the first chemotherapy course.

Per patient, both the interview and B-IPQ were compared with the drawings to check whether the latter provided an overall picture of the emotional impact of alopecia. The descriptive statistics were performed using IBM SPSS Statistics for Windows, version 24 (IBM Corp., Armonk, N.Y., USA).


  Results Top


Patients' sociodemographic and clinical characteristics are summarized in [Table 1]. All patients were Caucasian, most had breast cancer, had not experienced alopecia before, and used a head cover. Half of them had scalp cooling, and the mean patient-rated score of hair loss was 59 (standard deviation 37 on a 0–100 scale).
Table 1: Patient characteristics (n=15)


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Interview

The domains retrieved from the interviews are shown in [Table 2]. All the ten patients who were confronted with alopecia mentioned its emotional impact: disappointment and insecurity, sadness, shame, and confrontation. The physical aspects, such as the offset of alopecia, were experienced in different ways and described as pain, coldness, or change of hair structure. Most of the patients cut their hair when the alopecia started. They did not want to be confronted with the continuous loss of their hair anymore as it made them sad.
Table 2: Domains from the interviews


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The main reason given for wearing a wig (n = 7) was that patients could be anonymous again. “I can just go to the supermarket without anyone staring at me” (patient 6). Because of the wig, patients felt less reminded about their illness “Sometimes I just don't want to look like a patient, for example when you go out for dinner or something like that” (patient 12). Two patients indicated that they wore a wig because of their children “I chose a wig for my children because it looks less confronting” (patient 9). Disadvantages of a wig were also mentioned. Four patients said that they found their wig uncomfortable: warm and hard to style and it did not look like their own hair. Four patients mentioned the loss of eyebrows and/or lashes. They said it was hard to make particular facial expressions because of this loss. Some people shared more moderate opinions that they were less concerned about their hair loss. Two patients saw their hair loss as an associated side effect of cancer and were less worried about it.

Drawings

All the 15 patients were able to finish the drawings, see examples in [Figure 1]. Four patients who were having scalp cooling and one without scalp cooling did not wear any head covering, so they only created the first two drawings. Every patient drew their face and the physical condition of their hair. The facial expressions were positive in eight drawings (53%) and neutral in seven drawings before the start of the chemotherapy. In the second drawings, i.e., during chemotherapy, facial expressions were positive in five drawings (36%), neutral in nine drawings, and negative in one drawing. In the drawings with head covering, there were seven positive (70%) and three neutral drawings (30%). There was only one patient who drew three different emotions [Figure 1]a. Three other patients drew a difference in emotion; two were positive before (I) and neutral during chemotherapy (II). One patient drew a difference in emotion during chemotherapy: the second drawing was neutral and the third was positive [Figure 1]f.
Figure 1: Examples of drawings before (I) and during chemotherapy, with (II) and without head cover (III). (a) Patient 10. (b) Patient 9. (c) Patient 14. (d) Patient 3. (e) Patient 5. (f) Patient 1

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The text beneath the drawings gave extra information for 12 patients [Table 3]. Words including happy, terrible, confronting, and excited described how patients felt at that moment. However, in eight of these patients, no emotions were evident in their drawings [e.g. [Figure 1]b,[Figure 1]c,[Figure 1]d. The written text of four patients added extra physical details [Figure 1]e.
Table 3: Written text categorized in domains and drawings (I, II or III)


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The domains of the written text are summarized in [Table 3]. Positive emotions were mostly mentioned beneath drawings I and III. Six patients used colors in their drawings. Only one patient expressed how she experienced alopecia by using colors [Figure 1]a. Other patients only used colors to emphasize physical aspects such as hair color or make-up. The loss of eyebrows/eyelashes was seen in the drawings of four patients.

Brief Illness Perception Questionnaire

The mean scores on the B-IPQ are listed in [Table 4]. Most scores were between 0 and 4. Overall, the B-IPQ showed that the cognitive and emotional impact of alopecia was low to moderate, and patients felt that they understood their alopecia well. Patients in this study answered lower on each item compared to a previous study where the B-IPQ was utilized to measure the illness perceptions of cancer among women with breast cancer.[21] The answers to the open question regarding the most important consequences of alopecia were categorized into emotional (n = 11), social (n = 4), and physical (n = 6) domains [Table 5].
Table 4: B-IPQ scores regarding perception of alopecia compared with a reference group of perception of breast cancer


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Table 5: Open question B-IPQ categorized in domains (the numbers represent the number of patients that mentioned this)


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Association between drawings, Brief Illness Perception Questionnaire, and interviews

In ten patients, findings from the drawings with the additional text matched findings from the interviews and B-IPQ and showed the impact of alopecia on several domains. The themes that emerged from the interview were the confrontation and emotional reaction to alopecia, shame, and the loss of eyebrows and eyelashes. The B-IPQ provides insight into the emotional impact perception. The main similarities with the drawings without additional text were the physical aspects: amount/degree of hair loss and the choice for any head covering. The emotional aspects were only sometimes similar to the facial expressions in the drawings. Association on emotions was mainly found because of the text below the drawings.

It appeared that some details about hair loss, such as reasons to choose for scalp cooling and/or head covering, as well as the experienced confrontation with alopecia only, emerged from the interviews. In five patients, the interview had added value for determining the impact of alopecia, mainly about personal issues, such as the failure of scalp cooling or the impact of alopecia on the patient's job.


  Discussion Top


To our knowledge, this is the first study to explore the impact of chemotherapy-induced alopecia with drawings. Patients expressed the impact of hair loss differently in drawings compared to questionnaires or interviews only for the physical aspects. The amount of hair loss was depicted in drawings more clearly than patients mentioned in interviews. However, there was minimal change of emotions visible in the drawings, and it was not clear whether patients deliberately drew emotions associated with the hair loss. The drawing instructions mainly asked about the physical aspects of alopecia and did not ask about the emotional aspects, which is crucial to learn about the overall impact.[22],[23] Hence, using the current method, only combined with a text below the drawings, the overall view is comparable to an interview and the B-IPQ. Drawings combined with the B-IPQ provided a complete overview of the impact of alopecia, and the interviews mainly added extra details.

The mean perceptions of the B-IPQ scores for alopecia were relatively low in comparison with that of the reference group [Table 4]. It seems that the perception of alopecia is less severe than the perception of breast cancer itself. However, the text below the drawings as well as the open I-BPQ question, and the interview, showed that alopecia was confronting to almost all patients and did affect their life on several domains. This is in line with the literature.[3],[10],[24],[25],[26]

This study had some limitations. First of all, the patients did not draw emotional aspects, therefore it is advised that the instructions are adapted. The suggested instructions are We want to ask you to draw your feelings about your appearance of what your head and hair looked like before the start of the chemotherapy (drawing I), during chemotherapy without head covering (drawing II), and (if applicable) another drawing with head covering (drawing III). We are not interested in your drawing talent, a simple sketch is fine. We are interested in your ideas about any changes in your appearance and your feelings about it, only of your head and hair. Explain your feelings beneath the drawings on the dashed line.

Besides, patients did not add at least some words under each drawing. They should be motivated to do so in future studies as the text is important to get a complete view of alopecia, especially when there is no additional interview or questionnaire about hair loss.

Another limitation is that the written texts and interviews were transcribed and analyzed by only one researcher, which might have caused interviewer bias. Besides, the scoring sheet for the drawings did not include ratings of differences in emotions between drawings within patients. In order to limit subjectivity, this latter aspect will be adjusted in the sheet for a future drawing study.


  Conclusion Top


The drawing method is feasible to retrieve knowledge about the emotional impact of alopecia. As the impact of alopecia seems to be underestimated by health-care professionals,[14] drawings could lead to new insights and ultimately to improved patient information to cope with alopecia and support patients. Drawings made with the new instructions are expected to reveal different domains of how patients experience alopecia and specifically the course of their perceptions about alopecia over time.[15]

Informed consent

Informed consent was required for this study and was obtained from all individual participants included in the study.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Smith K, Winstanley J, Boyle F, O'Reilly A, White M, Antill YC. Madarosis: A qualitative study to assess perceptions and experience of Australian patients with early breast cancer treated with taxane-based chemotherapy. Support Care Cancer 2018;26:483-9.  Back to cited text no. 1
    
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Freites-Martinez A, Shapiro J, van den Hurk C, Goldfarb S, Jimenez J, Rossi AM, et al. CME Part 2: Hair disorders in cancer survivors persistent chemotherapy-induced alopecia, persistent radiotherapy-induced alopecia, and hair growth disorders related to endocrine therapy or cancer surgery. J Am Acad Dermatol 2019; 80:1199-1213.  Back to cited text no. 2
    
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Cho J, Choi EK, Kim IR, Im YH, Park YH, Lee S, et al. Development and validation of Chemotherapy-induced Alopecia Distress Scale (CADS) for breast cancer patients. Ann Oncol 2014;25:346-51.  Back to cited text no. 10
    
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Freedman TG. Social and cultural dimensions of hair loss in women treated for breast cancer. Cancer Nurs 1994;17:334-41.  Back to cited text no. 13
    
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Ramondt S, Tiemensma J, Cameron LD, Broadbent E, Kaptein AA. Drawings of blood cells reveal people's perception of their blood disorder: A pilot study. PLoS One 2016;11:e0154348.  Back to cited text no. 16
    
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Broadbent E, Niederhoffer K, Hague T, Corter A, Reynolds L. Headache sufferers' drawings reflect distress, disability and illness perceptions. J Psychosom Res 2009;66:465-70.  Back to cited text no. 17
    
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Ishida K, Ishida J, Kiyoko K. Psychosocial reaction patterns to alopecia in female patients with gynecological cancer undergoing chemotherapy. Asian Pac J Cancer Prev 2015;16:1225-33.  Back to cited text no. 25
    
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  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

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